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In this Review, we discuss the shared transcriptional mechanisms that regulate the development and/or the effector functions of innate and adaptive immune cells. We review the role of T-bet in.
T-bet (Tbx21) is an immune cell transcription factor originally described as the master regulator of Th1 cell development, although is now recognized to have a role in both the adaptive and innate immune systems. T-bet also directs T-cell homing to pro-inflammatory sites by the regulation of CXCR3 expression.In this review, we discuss how T-bet expression drives autoaggressive and inflammatory processes and how its function in vivo must be delicately balanced to avoid disease.
Despite recent advances, a number of questions remain regarding the basic biology of T-bet + B cells and their functional niche within the immune system. Herein, we review the discovery and defining characteristics of the T-bet + B cell subset in both mice and humans. T-bet is a Th1-specific transcription factor that plays a central role in Th1 development. T-bet transactivates the IFNγ gene, induces IFNγ production in retrovirally transduced primary T cells, and redirects polarized Th2 cells into the Th1 pathway.t betOriginally described over a decade ago as a T cell transcription factor regulating T helper 1 cell lineage commitment, T-bet is now recognized as having an important role in many cells of the adaptive and innate immune system.
In this Review, we highlight the events that led to the discovery of T-bet and eomesodermin (EOMES) and how models of infectious disease have helped to understand the broader functions of.t bet The evolving role of T In this Review, we highlight the events that led to the discovery of T-bet and eomesodermin (EOMES) and how models of infectious disease have helped to understand the broader functions of.
T-bet was originally described as the key transcription factor defining type 1 T helper (Th) cells. However, it is now clear that it drives the orchestrated generation of effector and memory cells in multiple different lymphocyte lineages.
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